C2. Uplink performance of MIMO multi-hop LTE-A based on Link Adaptation Multi-hop cellular network with relay components is a major concern in research studies around the world. This is due to the fact that it can aid the cell to achieve coverage extension, throughput and capacity enhancement. LTE-Advanced is the candidate from (3GPP) to meet (IMT)-Advanced requirements. This paper discuss the impact of RS placement on the LTE-Advanced Uplink performance using MIMO and AMC schemes, taking into consideration the effect of different arrival rates from random positioning UEs in the cell. Simulation results show the RS coverage area, total uplink cell throughput, and mean file transfer times for different RS positions with SISO-AMC (Adaptive Modulation and Coding) scheme and compare results with 2×2MIMO-AMC scheme.